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Published Clinical Trials On

Korean Red Ginseng

Korea Ginseng Research Institute

Korea Ginseng Corporation is pushing for innovation with the Korea Ginseng Research Institute at the helm. The Korea Ginseng Research Institute has 130 top researchers connected to medicine and science, both domestic and global. We study a variety of subjects, and we are world leaders in red ginseng and natural products research in areas ranging from ginseng cultivation technology to new ingredient development, efficacy/safety/analysis research, product development, and more.

Stress & Brain Health (Nootropics)

Effects of Ginseng Total Saponin on Caffeine-induced Stimulation of Locomotor Activity and the Related Brain Catecholamine Contents in Mice

Hack Seang Kim (Department of Pharmacology, College of Pharmacy, Chungbuk National University)

Seo (Department of Pharmacology, College of Pharmacy, Chungbuk National University)            

The effect of ginseng total saponins (GTS) on caffeine-induced increased locomotor activity was investigated. Catecholamines, noradrenaline and dopamine, possible mediators for the locomotor activity, were measured in the mouse whole brain, cortex and the remainder. The locomotor activity was measured in circular activity cages equipped with six light sources and photocells. Catecholamine contents in the mouse brain were determined by HPLC-fluorescence detection. GTS reduced the increased locomotor activity dose-dependently.

Conclusion

Caffeine increased the norepinephrine and dopamine in the mouse’s whole brain and cortex dose-dependently. Ginseng Total Saponin reduced the norepinephrine in the remainder, and reduced the dopamine in the cortex.


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An Open-Label Trial of Korean Red Ginseng As An Adjuvant Treatment for Cognitive Impairment in Patients with Alzheimer’s Disease

J-H Heo  1 , S-T Lee, K Chu, M J Oh, H-J Park, J-Y Shim, M Kim

Ginseng is one of the most popular herbs worldwide. Ginseng has various medical applications, and it seems to have significant effects as a cognition-enhancing drug. In this study, we examined the efficacy of Korean red ginseng (KRG) as an adjuvant therapy to conventional anti-dementia medications in patients with Alzheimer's disease.

Results

The patients in the high-dose KRG group showed significant improvement on the ADAS and CDR after 12 weeks of KRG therapy when compared with those in the control group (P = 0.032 and 0.006 respectively). The KRG treatment groups showed improvement from baseline MMSE when compared with the control group (1.42 vs. -0.48), but this improvement was not statistically significant.

Conclusions

This study suggests Korean Red Ginseng Extract showed good efficacy for the treatment of Alzheimer's disease.

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Effects of 8 Weeks Administration of Korean Panax Ginseng Extract On the Mood and Cognitive Performance of Health Individuals

Results

Data from the 16 participants that completed the study showed that there were no significant, acute treatment related differences on Day 1 of treatment, or in gluco-regulatory parameters throughout the study. However, time related performance improvements were evident following chronic administration of ginseng on the '3-Back' and 'Corsi-block' computerized working memory tasks. Ginseng was also associated with an improved score on the 'social relations' subscale of the WHOQOL-100, and a significant shift on the 'calm' factor of the Bond-Lader mood scales (from calm/relaxed towards excited/tense).

Conclusion

The results of the study suggest that Korean ginseng extract can modulate working memory performance and subjective ratings of 'quality of life' and mood.       

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Korean Red Ginseng Saponins with Low Ratios of Protopanaxadiol and Protopanaxatriol Saponin Improve Scopolamine-induced Learning Disability and Spatial Working Memory in Mice

Sung-Ha Jin a, Jin-Kyu Park a, Ki-Yeul Nam a, Sue-Nie Park b,*, Noh-Pal Jung c

a Department of Biochemical Pharmacology, Korea Ginseng & Tobacco Research Institute, PO Box7, Yusong-Gu, Taejon 305-345, South Korea

b Molecular & Cell Biology Research Division, Korea Research Institute of Bioscience & Biotechnology, KIST, PO Box 115, Yusong-Gu, Taejon 305-600, South Korea

c Department of Biology, College of Science, Yonsei University, Seoul 120-749, South Korea

Results

The ratio of PD and PT was 1.24 and 1.46, respectively. Before training, the ginseng saponins were administered intraperitoneally at doses of 50 and 100 mg/kg. The two saponins improved the scopolamine-induced learning impairment at different dosages in mice, 50 and 100 mg/kg, respectively.

Conclusion

Korean red ginseng saponin with a low PD/PT ratio had an improving effect on spatial working memory, but the saponin with a high PD/PT ratio did not. This finding suggests that the PD/PT ratio of the ginseng saponins may be an important factor in the pharmacological role of red ginseng as a medicinal herb.

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Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia

Guizhi Zhang a , Ailing Liu a , Yingbin Zhou a , Xun San a , Taowei Jin b , Yi Jin a,∗

a Department of Physiology, Medical College of Qingdao University, 308 Ningxia Road, Qingdao 266071, PR China

b Changchun University of Traditional Chinese Medicine, Changchun 130117, PR China

Results

Neurological responses and memory ability of the ginsenoside Rg 2 or nimodipine groups improved significantly compared with the VD group. The expression of BCL-2 and HSP70 were decreased, while BAX and P53 were increased in the VD model. The expression of BCL-2 and HSP70 proteins were increased, while BAX and P53 decreased after ginsenoside Rg 2 (2.5, 5 and 10 mg/kg) and nimodipine (50 g/kg) treatment compared with the VD group. The study suggests that ginsenoside Rg 2 improved neurological performance and memory ability of VD rats through mechanisms related to anti-apoptosis

Conclusions

The capacity for ginsenoside Rg 2 to modulate the expression of apoptotic related proteins suggests that ginsenoside Rg 2 may represent a potential treatment strategy for vascular dementia or other ischemic insults

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Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults

Jonathon L. Reay1 *, Andrew B. Scholey2 and David O. Kennedy1

1Brain Performance and Nutrition Research Centre, Northumbria University, Newcastle Upon Tyne, UK

2NICM Centre for the Study of Natural Medicines and Neurocognition, Brain Science Institute, Swinburne University, Melbourne, VIC 3122, Australia

Results

Results revealed dose-related treatment effects ( p < 0.05). Two hundred milligrams slowed a fall in mood at 2.5 and 4 h on day 1 and at 1 and 4 h on day 8, but slowed responding on a mental arithmetic task across day 1 and at 1 and 2.5 h on day 8. The 400 mg dose also improved calmness (restricted 2.5 and 4 h on day 1) and improved mental arithmetic across days 1 and 8

Conclusions

This study suggests Panax Ginseng improves aspects of working memory and improves calmness

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Administration of red ginseng ameliorates memory decline in aged mice

Yeonju Lee, Seikwan Oh*

Department of Molecular Medicine and TIDRC, School of Medicine, Ewha Womans University, Seoul, Korea

Results

Red ginseng treatment suppressed the production of age-processed inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-a, and interleukin-1b expressions. Moreover, it was observed that red ginseng had an antioxidative effect on aged mice. The suppressed glutathione level in aged mice was restored with red ginseng treatment. The antioxidative-related enzymes Nrf2 and HO-1 were increased with red ginseng treatment.

Conclusions

The results revealed that when red ginseng is administered over long periods, age-related decline of learning and memory is ameliorated through anti-inflammatory activity.

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Women's Health

Protective effects of red ginseng extract against vaginal herpes simplex virus infection

Ara Cho #, Yoon Seok Roh #, Erdenebileg Uyangaa, Surim Park, Jong Won Kim, Kyu Hee Lim,

Jungkee Kwon, Seong Kug Eo, Chae Woong Lim, and Bumseok Kim *

Biosafety Research Institute and College of Veterinary Medicine, Chonbuk National University, Jeonju 561-756, Korea

Results

Balb/c mice were administered with 100, 200, and 400 mg/kg oral doses of KRG extract for 10 d and then vaginally infected with HSV. We found that KRG extract rendered recipients more resistant against HSV vaginal infection and further systemic infection, including decreased clinical severity, increased survival rate, and accelerated viral clearance. Such results appeared to be mediated by increased vaginal IFN-γ secretion. Moreover, increased mRNA expression of IFN-γ, granzyme B, and Fas-ligand was identified in the iliac lymph node and vaginal tracts of KRG extract treated groups (200 and 400 mg/kg).

Conclusions

These results suggest that the activities of local natural killer cells were promoted by KRG extract consumption and that KRG may be an attractive immune stimulator for helping hosts overcome HSV infection.

Read The Full Study Here 

Skin & Hair Health

Làm cách nào tôi có thể nhận được sự hỗ trợ nếu tôi cần?
Chào mừng Bản thân cơn đau là rất quan trọng, và sự béo lên của lớp mỡ là kết quả, nhưng nó xảy ra vào thời điểm đó sẽ xảy ra một số đau đớn và lao động rất lớn. Trong những năm qua, tôi sẽ đến
Làm cách nào tôi có thể nhận được sự hỗ trợ nếu tôi cần?
Bản thân cơn đau là rất quan trọng để đạt được mức tăng cân lành mạnh, nhưng đồng thời nó cũng xảy ra với rất nhiều công việc và đau đớn. Trong những năm qua, tôi sẽ đến
Làm cách nào tôi có thể nhận được sự hỗ trợ nếu tôi cần?
Bản thân cơn đau là rất quan trọng để đạt được mức tăng cân lành mạnh, nhưng đồng thời nó cũng xảy ra với rất nhiều công việc và đau đớn. Trong những năm qua, tôi sẽ đến
Photoprotective Effect of Red Ginseng against Ultraviolet Radiation-induced Chronic Skin Damage

Hae June Lee 1, Joong Sun Kim2 , Myoung Sub Song2 , Heung Sik Seo2 , Changjong Moon2, Jong Choon Kim2 , Sung Kee Jo 3 , Jong Sik Jang4 and Sung Ho Kim 2*

1 Korea Institute of Radiological and Medical Science, Seoul 139-240, South Korea

2 College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, South Korea

3 Advanced Radiation Technology Institute, Jeongeup Campus of Korea Atomic Energy Research Institute, Jeongeup 580-185, South Korea

4 Department of Animal Science, Kyungpook National University, Sangju 742-711, South Korea

Background

Red ginseng has been found to protect the skin from photodamage by reducing the occurrence of UV radiation-induced skin tumors in mice. The mice treated with red ginseng showed a decreased wrinkling score, minimal epidermal hyperplasia, and slightly increased dermal cellularity, compared to the untreated mice. The treated mice also showed a significantly decreased tumor onset compared to the untreated mice.

Conclusion

It is noted that skin that is chronically exposed to UV is subject to photoaging and photocarcinogenesis and the regular use of Red Ginseng would prevent these photodamaging effects of UV.


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Red Ginseng Extract Promotes the Hair Growth in Cultured Human Hair Follicles

Gyeong-Hun Park,1 Ki-young Park,2 Hong-il Cho,2 Sang-Min Lee,3 Ji Su Han,3 Chong Hyun Won,3,* Sung Eun Chang,3 Mi Woo Lee,3 Jee Ho Choi,3 Kee Chan Moon,3 Hyoseung Shin,4 Yong Jung Kang,5 and Dong Hun Lee5, *

1 Department of Dermatology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.

2 Asan Institute for Life Sciences, Seoul, Korea.

3 Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

4 Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, Korea.

5 Department of Dermatology, Seoul National University College of Medicine, Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Korea

Results

Ginseng has been shown to promote hair growth, but its effects on human hair follicles and mechanisms of action are not well-understood. This study aimed to investigate ginseng's effects on cultured human hair follicles using Ki-67 immunostaining, as well as its effects on isolated human dermal papilla cells using cytotoxicity assays, immunoblot analysis of signaling proteins, and determination of associated growth factors. We also examined its ability to protect hair matrix keratinocyte proliferation against DHT-induced suppression and its effects on androgen receptor expression.

Conclusion

Red ginseng may promote hair growth in humans. It enhances hDPC proliferation, activates ERK and AKT signaling pathways, and inhibits the DHT-induced transcription of the androgen receptor.

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Red ginseng oil promotes hair growth and protects skin against UVC radiation

Van-Long Truong a, c , Young-Sam Keum b, Woo-Sik Jeong a, c, *

a Department of Food and Life Sciences, College of BNIT, Inje University, Gimhae, 50834, South Korea

b College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University, Goyang, 10326, South Korea

c Food and Bio-industry Research Institute, School of Food Science & Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu, 41566, South Korea


Background

Red ginseng oil can enhance skin functions, including hair growth and skin protection. In the hair growth experiment, shaved dorsal skins of C57BL/6 mice were topically applied with vehicle, RGO, RGO's major compounds, or minoxidil for 21 days. The skin tissues were examined for the hair growth promoting capacity.

Result

Topical application of RGO promotes hair regeneration by inducing early telogen-to-anagen transition, increasing the density and bulb diameter of hair follicles, and upregulating hair growth related proteins. In SKH-1 hairless mice, RGO has a protective effect against UVC-induced skin damage by inhibiting inflammation and apoptosis and inducing cytoprotective systems.

Conclusion

The data suggests that Red Ginseng Oil may be a potent agent for improving skin health and thereby preventing and/or treating hair loss and protecting skin against UV radiation


Read The Full Study Here

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